The Spanish referee Antonio Mateu Lahoz will officiate Atalanta-RB Leipzig, the return leg of the 2021-2022 UEFA Europa League quarter-finals. His assistants will be Pau Cebrián Devís (ESP) and Roberto del Palomar (ESP), fourth official José Luis Munuera (ESP), V.A.R. Juan Martínez Munuera (ESP), A.V.A.R. Ricardo de Burgos (ESP).